Ideally, your muscle and fat tissue would be able to use insulin effectively. But if they can’t, this class of oral medications can help. They can also help reduce glucose production in your liver, according to the American Diabetes Association (ADA). If you do take a drug like rosiglitazone, or Avandia, or pioglitazone, or Actos, don’t be surprised if your doctor closely monitors your liver function, since an earlier drug in this class caused some liver damage in some patients. However, if the drugs work for you, you’re unlikely to experience any other side effects.